Recently, in a research report published in the internationally renowned magazine Science, researchers from institutions such as the Salk Genetics Laboratory conducted the first study on the molecular marker properties of microglia, which constitute the first-line immune defense mechanism of the brain. Description, the researchers found that microglia play a key role in the development of a variety of neurodegenerative diseases and mental illness, including Alzheimer's disease, Parkinson's disease, Huntington's disease, schizophrenia and so on. Researcher Rusty Gage said that microglia are an immune cell in the brain, but we don't know what it does in the human brain at present; this study not only links the cell to the disease, but It provides some clues for our later understanding of the biological mechanism of microglia. Previously, researchers believe that genes associated with neurological disease are expressed at higher levels in microglia than other brain cells. In the past, researchers have found that microglia are associated with a range of human diseases, and the researchers in this study have elucidated the molecular basis of this association. Image taken from: Nicole Coufal Professor Christopher Glass said that these studies clearly resolved microglia, and the results may help us determine the beneficial or pathological function of microglia. At the same time, microglia are also a class of macrophages that can help destroy pathogens and exogenous substances in the body. These cells are known to be very sensitive to the surrounding environment and can release pro-inflammatory properties. Or anti-inflammatory signals to respond to changes in the brain. When the cells are damaged or in a disease state, the microglia can "cut" the connections between the neuronal cells.
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