New findings in the treatment of spinal cord injury

New findings in the treatment of spinal cord injury

August 03, 2018 Source: Health News Network

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Recently, Academician of the Chinese Academy of Engineering, Professor Gu Xiaosong of Nantong University and He Zhigang Research Group of Harvard Medical School collaborated to publish papers online in the international authoritative academic journal Cell, which proved for the first time that the disorder of excitability of interneurons is a hindrance function after spinal nerve injury. An important mechanism for sexual recovery, and a new treatment strategy that can effectively improve functional recovery by balancing the excitability of inhibitory neurons in the spinal cord.

According to data provided by the World Health Organization, more than 5 million people have spinal cord injuries in China. Yu Bin, a professor and member of the research team at Nantong University, said that more than 90% of patients with spinal cord injury are not completely anatomically anatomically damaged. After the injury, some residual nerve fibers are still connected to the two ends of the damaged spinal cord. Half of the patients were completely lost in function. At present, clinical functional recovery after spinal cord injury is a major medical problem that has not yet been solved in the world. The means and efficacy of clinical treatment are very limited. The root cause of this condition is that the mechanism that hinders functional recovery after spinal cord injury is unclear.

In the past 5 years, Academician Gu Xiaosong and He Zhigang have focused on the functional recovery mechanism after spinal cord injury, and directly researched and screened small molecule drugs as a breakthrough to study and establish a complete and globally leading research system for central nervous system damage repair. And methods. They have found that by regulating the cell membrane ion channel protein KCC2, it can effectively antagonize the excitability of inhibitory neuronal cells, improve the excitability and imbalance of interneurons caused by spinal cord injury, and strengthen the "brain-spinal" nerve bypass signal. The delivery, thus effectively enhancing the recovery of motor function.

According to Yu Bin, the findings subvert the traditional research on the mechanism of functional recovery after spinal cord injury, focusing on the excitatory stimulation of traditional neuronal excitatory stimulation and balancing the excitability of neurons. This discovery is expected to be an important direction to study the mechanism of spinal cord injury and a new target for the treatment of patients with spinal cord injury. It provides a theoretical basis for neurological functional recovery therapy for patients with spinal cord injury, and can bring new diseases to patients with spinal cord injury clinically. Treatment measures. (Correspondent Wang Ying special correspondent Shen Dalei)

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