"Lancet" published the latest achievements of the Chen Zijiang team: "frozen single embryo transfer" can significantly improve the success rate of IVF

On February 28th, the Journal of The Lancet (Impact Factor: 53.254) published an article entitled "Comparison of fresh single blastocyst transfer in ovulatory women in vitro" (Frozen versus fresh single blastocyst transfer in ovulatory women) : a multicenter, randomized controlled trial), reveals that frozen single embryo transfer can significantly improve the implantation rate of embryos, providing a valuable evidence-based basis for single-embryo embryo transfer strategy.
This achievement is another national multi-center prospective randomized controlled clinical trial completed by Professor Chen Zijiang from Shandong University. It is another major breakthrough in the “Freeze-only strategy” (the first two studies) In 2016 and 2018, it was published in the top medical journal "New England Journal of Medicine".

It is worth noting that the "Lancet" published a special review by Professor Christos Coutifaris, President of the American Society for Reproductive Medicine (ASRM), which comprehensively summed up a series of research results of the "Full Embryo Freezing Strategy" led by Shandong University. The team's series of research results have made important contributions to the clinical decision-making of international reproductive medicine.

What is the whole embryo freezing strategy?

Embryo transfer is a key step in the process of "test tube baby", and "full embryo freezing strategy" is a brand new concept of embryo transfer, that is, freezing all embryos, avoiding high estrogen environment transplantation in ovulation induction, elective period in physiological cycle Transplant the thawed resuscitation embryo.
However, this program has been lack of high-quality evidence-based evidence and clinical outcome observations, which is very controversial. Professor Chen Zijiang has organized a number of national multi-center randomized controlled clinical studies in recent years, dedicated to the demonstration and analysis of the outcomes of frozen embryo transfer and fresh cycle transplantation in different populations, and obtained valuable clinical research results, which have a major impact at home and abroad. .

Latest Lancet: Freezing single embryo transfer can increase success rate

DOI: https://doi.org/10.1016/S0140-6736(18)32843-5

In this new study, the Chen Zijiang team is once again at the forefront – assessing the impact of frozen single embryo transfer and fresh single embryo transfer on the success rate of “test tube baby”.
They collaborated with Professor Richard S Legro of the internationally renowned expert Penn State University and Professor Zhang Heping of Yale University to set up an academic steering committee to elaborate the “Study on the effectiveness and safety of frozen and fresh single blastocyst transfer” program. A large-scale clinical study was conducted at the clinical center.
They included a total of 1,650 infertile subjects treated with fertilization-embryo transfer (IVF). The results showed that compared with the traditional fresh single blastocyst transfer, single embryo transfer after whole embryo freezing can significantly improve embryo implantation rate, pregnancy rate and live birth rate, as well as the birth weight of single-born newborns, significantly improved. The maternal and child safety and clinical outcomes of IVF provide a valuable evidence-based basis for single-embryo embryo transfer strategies.
Care should be taken that the research team also observed a slight increase in the risk of preeclampsia in mothers undergoing cryopreserved single blastocyst transfer, which provided an important warning for the clinical application of the program, providing a broader perspective for embryo culture and cryo-freezing technology. And deep research explores space.
Reference materials:
The original research results of reproductive medicine in Shandong University were published in the "Lancet". Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial

Source: Bio-Exploration

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