The first is to prevent low temperature and humidity. Low temperature and humidity are not conducive to the growth and development of silkworms, and are also likely to cause fungal disease outbreaks. Therefore, when the temperature is too low at night, it is necessary to appropriately perform temperature-warming and dehumidification. When heating, care should be taken to avoid the use of bald coal stoves to prevent silkworm gas poisoning. The second is the occurrence of silkworm disease. In order to control the occurrence of silkworm disease in the later period, fresh lime powder plus extinction spirit is used once a day to disinfect the silkworm body of silkworm, and it has been used more than twice a day. Bacterial disease should be given antibiotics such as coleoptera. Strengthen the control of fly maggots, you can use the flies to add food or body spray. The time of administration was between 4 and 5 years, namely the third day of the fourth instar and the second, fourth, sixth and upper jaw of the fifth instar. The method of adding the food was: 500 ml of water per ml of silkworm flies was sprayed evenly on 5 kg of mulberry leaves. The body spray method is as follows: 300 milliliters of water per milliliter of silkworm flies solution is sprayed to the mulberry precursor, and the leaves are fed after the silkworm crawls. The third is prevention of pesticide poisoning. It is necessary to prevent silkworm poisoning caused by pollution of rice, vegetables, pesticides, and industrial “three wastesâ€. Strengthen the mulberry leaf test feeding, after test feeding to ensure the normal use of leaves after non-toxic. Due to agricultural pest control and industrial pollution and other reasons, the poisonous and harmful substances in the air are gradually increased in the air, contaminating the mulberry leaves, and the silkworms are prone to cumulative poisoning after long-term consumption. It is recommended that the polluted mulberry leaves be sprayed or reclaimed in the field after clean water spraying. After rinsing with clean water, the heavily polluted mulberry leaves can be soaked and rinsed with 1% fresh lime water, dried and fed with silkworms to minimize the impact of pollution. In case of crop pest control, the silkworm room located under the crops should promptly close the doors and windows, prevent pesticide poisoning from causing silkworm poisoning, eliminate the smell of air pesticides, open the door and open windows for ventilation, and keep silkworm indoor air fresh. The fourth is the prevention of silkworm enclosures. Large silkworm should strengthen ventilation in the latter part of the period. In low temperature weather conditions, coordination of ventilation and heat preservation should be done. When the temperature is normal during the day, more ventilation is required. When the temperature is too low at night, attention should be paid to scientific insulation or proper heating. The fifth is the protection of silkworm heads. The dense silkworm nest not only causes scavengers, but also easily causes wounds and infects silkworm diseases. Therefore, it is necessary to pay attention to thinning silkworms and to prevent excessive density, so as to achieve two silkworms. Medicine Peptides and protein drugs are emerging. There are now 35 important therapeutics on the market, and the development of biotechnology and biopharmaceutical companies is becoming increasingly global. Biotechnology drug research focuses on the application of DNA recombinant technology to develop peptides, proteins, enzymes, hormones, vaccines, cell growth factors and monoclonal antibodies that can be used in clinical applications. According to Parexl's Pharmaceutical R&D Statistical Source Book, there are currently 723 biotech drugs under FDA review (including phase â…° to iii clinical and FDA evaluation), 700 drugs are in early stage (research and preclinical). More than 200 additional drugs are in the final stage of approval (Phase iii clinical and FDA evaluation). The basic dosage form of biotech drugs is lyophilized. Although the efficacy of conventional preparations has long been clinically proven, they need to be injected frequently for a long time due to their short half-life, which is difficult to accept from the perspective of psychological and economic burden on patients. To this end, scholars around the world mainly from two aspects to study and develop convenient and reasonable drug delivery approaches and new preparations: (1) embedment agent and sustained-release injection. â‘¡ Non-injectable dosage forms, such as respiratory inhalation, rectal administration, nasal administration, oral administration and transdermal administration, etc. Injectable preparations of sustained-release biotechnological drugs are new dosage forms with promising applications. Some of them, such as microsphere injections of luteinizing hormone releasing hormone (LHRH) analogues which can be sustained-release for 1 to 3 months, have been on the market. This paper focuses on this kind of preparations.Main types of peptides and protein drug sustained-release preparations The research and development of peptides and protein drug sustained-release preparations can be divided into two types, namely, embedment agent and microsphere injection, from the perspective of development process and dosage form. The shape of the implant is a hollow micro-fine rod, one end is closed, the other end is open, and the rod material is non-biodegradable polymer such as ptfe. The lumen was filled with a mixture of drugs and silica gel (silastic, polydimethylsiloxane). The implant is embedded under the skin, and the drug is released slowly through the opening of silica gel matrix. The American Physicians' Handbook (PDR) contains a product called Norplant? Levo-18 ethyl norethinnes, used in family planning. The preparation, each with a diameter of 2.4 mm and a length of 34 mm, is surgically implanted in the inner side of the patient's upper arm with 6 thin rods. The drug can be released in the body in zero-grade mode for up to 5 years, and then removed by surgery after release,1.1.2 Micro-osmotic pump embedding agent The United States Alza company in the 1970s developed an embedding agent shaped like a capsule, which is embedded in the skin or other parts. The body fluid can penetrate through the shell, dissolve the interlayer electrolytic layer, make the volume expansion of the interlayer pressure to the plastic inner cavity, and promote the drug solution from the opening of the fixed speed release. Many biomolecular drugs, such as insulin, heparin and nerve growth factor, have been reported as model drugs in vivo and in vitro. Implants have positive significance for the treatment of chronic patients who need long-term medication, but it has the following defects: â‘ must be surgically implanted. â‘¡ The skeleton material of the preparation is non-biodegradable polymer, which needs to be removed by surgery after release. â‘¢ The preparation has irritation and discomfort in local tissues. Evaluation methods for polypeptide protein drugs: 1. Liquid chromatography 2. Spectroscopic 3. Solvent-based versions are easy to use, but need to be kept at low temperatures (2-8 degrees Celsius). medicine peptides high,Peptide injections,buy medicine peptides high,medicine peptides for bodybuilding,medicine peptides for hgh Shaanxi YXchuang Biotechnology Co., Ltd , https://www.peptide-nootropics.com